If it feels like your leg is being forced to lean inwards or outwards then you need to move the calf cuff slightly to the right or left. I find if its pulling inwards then I need to twist them inward a little bit. Literally moving 5mm-10mm at a time will make a difference. Once you have it just right, tighten up that quick release good and tight.
If its not done tight then it can cause the cuffs to move should you fall or put excessive weight on one side and then you have to adjust them all over again.
I actually mark mine up with marker pen so if my cuffs ever move or someone else goes on them and changes them I can quickly get them back to exactly how I like it.